The Coast Guard gained an enviable reputation during the war
Some of the high points include:
| Name | Action | Model |
| Cutters Credited With WWII Sinkings | ||
| Icarus | Sank U-352 on 9 May 1942 | |
| McLane | Sank RO-32 on 9 July 1942 | |
| Ingham | Sank U-626 on 17 December 1942 | |
| Spencer | Sank either U-225 or (more likely) U-529 on 21 February 1943 | |
| Campbell | Sank U-606 on 22 February 1943 | Yes |
| Thetis | Sank U-157 on 13 June 1943 | |
| Coast Guard Manned Navy Ships Credited With WWII Sinkings | ||
| Joyce and Peterson | Sank U-550 on 19 April 1944 | |
| Pride and Menges | Sank U-371 on 4 May 1944 | |
| Rockford (PF) | Sank I-12 on 13 November 1944 | |
| Knoxville (CG Flagship of Hunter/Killer Group) | Group sank U-869 on 28 February 1945 | |
| Lowe, Menges, Pride, Mosley | Sank U-866 on 19 March 1945 | |
| Knoxville (CG Flagship of Hunter/Killer Group) | Group sank U-857 on 18 April 1945 | |
| Knoxville (CG Flagship of Hunter/Killer Group) | Group sank U-853 on 6 May 1945 |